Hey Mark,
Thanks for posting. Absolutely. There are a number of options depending on how you want to set things up with regard standings. For example, you could create two leagues – Pac-12 North and Pac-12 South for example. Then you can mark games as “Division” when it’s north v north or south v south. Then you can display standings tables for north and south, which display division records and overall records, and you can sort by either one – automagically if you have the LM Add-ons plugin, or by hand with the base MSTW League Manager.
Hope that helps.
-Mark